Tianeptine focuses on products 66981-73-5 Tianeptine Sodium

summarize

tianeputine, also known as stablon. Its chemical structure belongs to tricyclic antidepressants. Its mechanism of action is a drug 5-HT reuptake agonist with the exact opposite effect of selective 5-HT reuptake inhibitors.

Pharmacological action

Tineptine is a tricyclic antidepressant. It acts as an antidepressant by acting on the serotonin system. In animal experiments, it can increase the spontaneous activity of hippocampal pyramidal cells and accelerate the recovery of their function after inhibition. It can increase the reabsorption of serotonin by neurons in the cerebral cortex and hippocampus.

Pharmacokinetic characteristics

The study suggests that the product is absorbed rapidly and completely in the gastrointestinal tract, the protein binding rate is about 94%, the drug is metabolized by the liver, the elimination half-life (partial) is about 2.5 hours, its metabolites are mainly excreted by the kidney, and the prototype drug only accounts for 8%. Aged patients over 70 years old and long-term medication, the QII of this product increased by about 1 hour. Studies have shown that in patients with chronic alcoholism, pharmacokinetic parameters are not changed even when alcoholism causes cirrhosis. In patients with renal insufficiency, t1/2 increases by about 1 hour.